The Diabetic Complications chiefly includes injurious effects of hyperglycemia which are primarily separated into macro vascular complications and micro vascular complications. Macro vascular complication chiefly includes retinopathy and micro vascular includes neuropathy. Diabetic retinopathy is also the foremost common micro vascular complication of diabetes. It is responsible for ? 10,000 new cases of blindness every year in the United States alone. The risk of developing diabetic retinopathy or other micro vascular complications of diabetes depends on both the duration and the severity of hyperglycemia. Diabetic nephropathy is the leading cause of renal failure in the United States. It is defined by proteinuria > 500 mg in 24 hours within the setting of diabetes; however this can be preceded by lower degrees of proteinuria, or “micro albuminuria.